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Main Data
Editor: Joseph Anderson, MD, Charles Kahi, MD
Title: Colorectal Cancer Screening
Publisher: Humana Press
ISBN/ISSN: 9781607613985
Edition: 1
Price: CHF 184.80
Publication date: 01/01/2011
Content
Category: Medizin & Pharmazie
Language: English
Technical Data
Pages: 205
Kopierschutz: DRM
Geräte: PC/MAC/eReader/Tablet
Formate: PDF
Table of contents

Colorectal Cancer Screening provides a complete overview of colorectal cancer screening, from epidemiology and molecular abnormalities, to the latest screening techniques such as stool DNA and FIT, Computerized Tomography (CT) Colonography, High Definition Colonoscopes and Narrow Band Imaging. As the text is devoted entirely to CRC screening, it features many facts, principles, guidelines and figures related to screening in an easy access format. This volume provides a complete guide to colorectal cancer screening which will be informative to the subspecialist as well as the primary care practitioner. It represents the only text that provides this up to date information about a subject that is continually changing. For the primary practitioner, information on the guidelines for screening as well as increasing patient participation is presentedd. For the subspecialist, information regarding the latest imaging techniques as well as flat adenomas and chromoendoscopy are covered. The section on the molecular changes in CRC will appeal to both groups. The text includes up to date information about colorectal screening that encompasses the entire spectrum of the topic and features photographs of polyps as well as diagrams of the morphology of polyps as well as photographs of CT colonography images. Algorithms are presented for all the suggested guidelines.

Chapters are devoted to patient participation in screening and risk factors as well as new imaging technology. This useful volume explains the rationale behind screening for CRC. In addition, it covers the different screening options as well as the performance characteristics, when available in the literature, for each test. This volume will be used by the sub specialists who perform screening tests as well as primary care practitioners who refer patients to be screened for colorectal cancer.

Table of contents
Preface6
Contents8
Contributors10
Chapter 1: Colorectal Cancer Pathways12
Chromosomal Instability or Suppressor Pathways13
Microsatellite Instability or Mutator Pathway13
CpG Island Methylator Pathway16
References16
Chapter 2: Risk Factors and Screening for Colorectal Cancer18
Prospective Studies18
Risk Factors20
Red Meat20
Fiber Intake21
Physical Exertion21
Gender22
Alcohol22
Tobacco23
Obesity23
Diabetes Mellitus24
Race24
Asymptomatic Screening Populations25
Translation into Screening26
Models26
Screening Guidelines27
New Problems in Screening27
References28
Chapter 3: Hereditary Adenomatous Colorectal Cancer Syndromes35
Background35
Recognizing the Patient with a HCCS36
Hereditary Nonpolyposis Colorectal Cancer (HNPCC)37
Genetics37
Clinical Presentation39
Diagnosis40
Colon Cancer Surveillance41
Extracolonic Screening and Management41
Familial Adenomatous Polyposis41
Genetics42
Clinical Presentation42
Diagnosis44
Colon Cancer Screening and Surveillance44
Extracolonic Screening and Surveillance45
MYH-Associated Polyposis (MAP)46
Genetics46
Clinical Presentation46
Screening and Surveillance47
Conclusions47
References47
Chapter 4: Screening and Surveillance Guidelines52
Background52
Colorectal Cancer Screening53
Best Evidence for CRC Screening53
History of Screening Guidelines54
Current Recommendations for Average Risk Screening55
High Risk Screening56
Family History56
Tailored Screening58
Race59
Gender59
Tobacco59
Diabetes Melitus60
Surveillance60
Background60
Personal History of Adenomas61
Personal History of Colorectal Cancer62
References63
Chapter 5: Barriers to Colorectal Cancer Screening: Patient, Physician, and System Factors65
Patient Barriers to CRC Screening66
Provider Barriers to CRC Screening69
Systems Barriers to CRC Screening71
Reducing Barriers to CRC Screening71
References72
Chapter 6: Screening for Colorectal CancerUsing Colonoscopy75
Rationale and Efficacy for Screening Colonoscopy75
Failures of Colonoscopy to Prevent Proximal Colon Cancer78
Maximizing Colorectal Cancer Prevention During Colonoscopy83
Conclusions84
References84
Chapter 7: New Colonoscopic Technologies for Colorectal Cancer Screening88
Introduction88
Technologies for Improving Detection During Colonoscopy89
Improving Mucosal Exposure89
Imaging Technologies for Flat Lesions91
Technologies That Allow Real-Time Histology94
Conclusions97
References97
Chapter 8: Screening for CRC Using CT Colonography*102
Introduction102
Current Status of CT Colonography103
Guidelines and Recommendations106
Current Indications for CT Colonograpy108
CRC Screening of Asymptomatic, Normal-Risk Adults109
Failed Colonoscopy111
Evaluation of Colon Proximal to an Obstructing Lesion111
CRC Screening in Patients with Contraindications to Colonoscopy or Who Refuse Other Screening Options112
Contraindications for CT Colonograpy112
Qualifications and Training of Personnel113
CT Scanning113
Skill and Training to Interpret CT Colonography113
Exam and Equipment Specifications116
Colonic Preparation116
CT Acquisition Technique117
CT Colonography Interpretation and Polyp Reporting118
Intracolonic Findings118
Extracolonic Findings120
Potential for Increased Screening Uptake120
Integration of CT Colonogrpahy with Colonoscopy121
Conclusions121
References122
Chapter 9: Noninvasive Screening Tests129
Introduction129
Guaiac-Based Fecal Occult Blood Testing (FOBT)131