Main Data
Author: Arman T. Askari
Editor: Arman T. Askari, A Michael Lincoff
Title: Antithrombotic Drug Therapy in Cardiovascular Disease
Publisher: Humana Press
ISBN/ISSN: 9781603272353
Edition: 1
Price: CHF 226.10
Publication date: 01/01/2010
Category: Medizin & Pharmazie
Language: English
Technical Data
Pages: 475
Kopierschutz: DRM
Geräte: PC/MAC/eReader/Tablet
Formate: PDF
Table of contents

Substantial morbidity and mortality remains associated with thrombotic events has stimulated the rapid expansion of the available armamentarium to combat pathologic thrombosis. Pathologic thrombosis plays an essential role in the pathogenesis of acute coronary syndromes (ACS), ischemic complications of percutaneous coronary intervention (PCI), venous thromboembolic disease, and embolic complications of arrhythmias and various cardiomyopathies.

Written by experts in the field, Antithrombotic Drug Therapy in Cardiovascular Disease carefully examines individual and various combinations of the available antithrombotic regimens including fibrinolytic agents, antiplatelet therapies (aspirin, thieneopyridines, glycoprotein IIb/IIIa inhibitors), and anticoagulant therapies (unfractionated heparin, low-molecular-weight heparins, direct thrombin inhibitors, and synthetic factor X inhibitors), non-ST-segment elevation (NSTE) ACS and ST-segment elevation myocardial infarction (STEMI). A detailed overview, Antithrombotic Drug Therapy in Cardiovascular Disease presents the evidence demonstrating the efficacy of available antithrombotic therapies in specific disease states such as atrial fibrillation, cardiomyopathy, valvular heart disease, and heparin-induced thrombocytopenia (HIT).

Table of contents
Basic Principles13
Platelets in Arterial Thrombosis14
The Role of Coagulation in Arterial and Venous Thrombosis29
The Link Between Inflammation and Thrombosis49
The Genetics of Thrombosis72
Antithrombotic Therapy for Stable Coronary Atherosclerotic Disease124
Aspirin in Primary and Secondary Prevention of Cardiovascular Disease125
Thienopyridines in Stable Coronary Disease138
Antithrombotic Therapy for NSTE ACS149
Antiplatelet Therapies in Unstable Angina and Non-ST Segment Elevation Myocardial Infarction150
Unfractionated Heparin and Enoxaparin for the Management of Non- ST- Segment Elevation Acute Coronary Syndromes169
Direct Thrombin Inhibitors in Acute Coronary Syndromes186
Synthetic Factor Xa Inhibition in Acute Coronary Syndromes205
Antithrombotic Therapy for STEMI218
Antiplatelet Therapies: Aspirin, Clopidogrel and Thienopyridines, and Glycoprotein IIb/ IIIa Inhibitors for the Management of ST- Segment Elevation Myocardial Infarction219
Antithrombin Therapy for Acute ST-Segment Elevation Myocardial Infarction234
Fibrinolysis and Facilitated PCI246
Antithrombotic Therapy in Interventional Cardiology257
Antithrombotic Therapy in Percutaneous Coronary Intervention258
Antithrombotic Therapy in Carotid and Peripheral Intervention280
Monitoring of Antithrombotic Therapies in Interventional Cardiology303
Antithrombotic Therapy in Venous Thromboembolism325
Venous Thromboembolism326
Fibrinolysis for Pulmonary Embolism346
Duration of Anticoagulant Therapy After Venous Thromboembolism357
Clinical Consideration380
Antithrombotic Therapy for Atrial Fibrillation and Cardioversion381
Antithrombotic Therapy for Valvular Heart Disease396
Antithrombotic Therapy in Heart Failure and Cardiomyopathy415
Heparin-Induced Thrombocytopenia424
Resistance to Antiplatelet Drugs437