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Main Data
Author: Enrique Criado, Gilbert R. Upchurch Jr.
Editor: Gilbert R. Upchurch Jr., Enrique Criado
Title: Aortic Aneurysms Pathogenesis and Treatment
Publisher: Humana Press
ISBN/ISSN: 9781603272049
Edition: 1
Price: CHF 236.80
Publication date: 01/01/2009
Content
Category: Medizin & Pharmazie
Language: English
Technical Data
Pages: 381
Kopierschutz: DRM
Geräte: PC/MAC/eReader/Tablet
Formate: PDF
Table of contents

As life expectancy is extended, the incidence and occurrence of Aortic Aneurysms are becoming increasingly common. Until recently, the treatment of aortic disease was primarily surgical, carrying a high mortality rate among the high risk elderly population. In Aortic Aneurysms: Pathogenesis and Treatment, Gilbert R. Upchurch Jr., Enrique Criado, and a panel of distinguished physicians comprehensively assess the rapidly evolving field of aneurysm treatment, focusing on aneurysms of the descending thoracic and abdominal aorta. The discussion of Aortic Aneurysms covers endovascular aortic repair as well as the recent significant improvements in stent graft design. This volume provides a concise and authoritative view of the current state of patient management, serving as a primer on clinical care and surgical procedures for aortic aneurysms. Comprehensive and up-to-date, Aortic Aneurysms: Pathogenesis and Treatment, offers Cardiologists, Vascular Surgeons, and Thoracic and Cardiac Surgeons a multidisciplinary approach to the management and treatment of patients with aortic disease.

Table of contents
Foreword5
Preface6
Contents8
Contributors11
Chapter 116
Genetics of Abdominal Aortic Aneurysms16
Introduction16
Clinical Management and the Genetics of AAA19
Identification of AAA-Susceptibility Loci by Genome-Wide DNA Linkage Analyses20
Genetic Association Studies: From Candidate Gene Studies to Genome-Wide Analyses22
Microarray-Based Global Gene Expression Profiling: An Unbiased Approach to Identify Signaling Pathways Altered in AAA29
Animal Models Provide Important Information About Pathogenesis of AAA32
Conclusions: The Future of Aneurysm Genetics34
References35
Chapter 242
Inflammatory Pathogenesis and Pathophysiology of Abdominal Aortic Aneurysms42
Introduction42
The Genetic Basis of the Inflammatory Response in AAA45
Evidence of Inflammation in the Circulation of AAA Patients46
Conclusions47
References48
Chapter 350
Contemporary Imaging of Aortic Disease50
Introduction50
Computed Tomography52
Magnetic Resonance Imaging58
Catheter-Based Vascular Imaging65
References68
Chapter 471
Medical Management of Small Aortic Abdominal Aortic Aneurysms71
Clinical Problem of AAA71
Current Treatment Modalities73
Measuring Aneurysm Progression74
Factors Influencing Aneurysm Progression75
Tobacco75
Statins76
beta -blockers77
ACE Inhibitors and Angiotensin Receptor Blockers77
Macrolides78
Tetracyclines78
Considerations for Evaluating Medical Therapies79
References80