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Main Data
Author: Robert E. Anderson, Matthew M. La Vail, Joe G. Hollyfield
Editor: Robert E. Anderson, Matthew M LaVail, Joe G. Hollyfield
Title: Recent Advances In Retinal Degeneration
Publisher: Springer-Verlag
ISBN/ISSN: 9780387749044
Edition: 1
Price: CHF 234.00
Publication date: 01/01/2007
Content
Category: Medizin & Pharmazie
Language: English
Technical Data
Pages: 424
Kopierschutz: DRM
Geräte: PC/MAC/eReader/Tablet
Formate: PDF
Table of contents

The product of perhaps the most important research meeting in the field, this essential text outlines all the latest research in retinal degeneration. Culled from the proceedings of the International Symposium on the subject, the topics in this volume explore the etiology, cellular mechanisms, epidemiology, models and potential therapeutic measures for the blinding diseases of retinitis pigmentosa and age-related macular degeneration. A must-read for researchers in the field.

Table of contents
Dedication6
Preface7
Travel Awards9
Contents10
Contributors16
Keynote Lectures34
Curing Blindness with Stem Cells: Hope, Reality, and Challenges35
Retinal Degenerations: Planning for the Future53
Neuroprotection68
Neurotrophins Induce Neuroprotective Signaling in the Retinal Pigment Epithelial Cell by Activating the Synthesis of the Anti- inflammatory and Anti- apoptotic Neuroprotectin D169
On the Role of CNTF as a Potential Therapy for Retinal Degeneration: Dr. Jekyll or Mr. Hyde?75
Nanoceria Particles Prevent ROI-Induced Blindness82
An in-vivo Assay to Identify Compounds Protective Against Light Induced Apoptosis89
Role of BCL-XL in Photoreceptor Survival96
The Hypoxic Transcriptome of the Retina: Identification of Factors with Potential Neuroprotective Activity102
Gene Therapy and Neuroprotection113
Lentiviral Gene Transfer-Mediated Cone Vision Restoration in RPE65 Knockout Mice114
In vitro Analysis of Ribozyme-mediated Knockdown of an ADRP Associated Rhodopsin Mutation121
Gene Therapy for Mouse Models of ADRP131
Development of Viral Vectors with Optimal Transgene Expression for Ocular Gene Therapies137
Adeno-Associated Viral Vectors and the Retina144
Genetic Supplementation of RDS Alleviates a Loss- of- function Phenotype in C214S Model of Retinitis Pigmentosa152
Morphological Aspects Related to Long-term Functional Improvement of the Retina in the 4 Years Following rAAV- mediated Gene Transfer in the RPE65 Null Mutation Dog162
Virus-mediated Gene Delivery to Neuronal Progenitors170
Animal Models of Retinal Degeneration177
Loss of Visual and Retinal Function in Light- stressed Mice178
ERG Responses and Microarray Analysis of Gene Expression in a Multifactorial Murine Model of Age- Related Retinal Degeneration186
Oxygen Supply and Retinal Function: Insights from a Transgenic Animal Model192
Characterization of Gene Expression Profiles of Normal Canine Retina and Brain Using a Retinal cDNA Microarray199
Toward a Higher Fidelity Model of AMD205
The Potential of Ambient Light Restriction to Restore Function to the Degenerating P23H- 3 Rat Retina213
Molecular Genetics and Candidate Genes220
Mutations in Known Genes Account for 58% of Autosomal Dominant Retinitis Pigmentosa ( adRP)221
Genetics of Age-related Macular Degeneration228
Retinal Phenotype of an X-Linked Pseudo-usherSyndrome in Association with the G173RMutation in the RPGR Gene237
Mutation in the PYK2-Binding Domain of PITPNM3 Causes Autosomal Dominant Cone Dystrophy ( CORD5) in Two Swedish Families244
Identification and Characterization of Genes Expressed in Cone Photoreceptors250
Clinical and Genetic Characterization of a Chinese Family with CSNB1260
10q26 Is Associated with Increased Risk of Age- Related Macular Degeneration in the Utah Population268
Diagnostic, Clinical, Cytopathological and Physiologic Aspects of Retinal Degeneration274
Carboxyethylpyrrole Adducts, Age-related Macular Degeneration and Neovascularization275
A Possible Impaired Signaling Mechanism in Human Retinal Pigment Epithelial Cells from Patients with Macular Degeneration282
Expression and Cell Compartmentalizationof EFEMP1, a Protein Associated with Malattia Leventinese289
Role of ELOVL4 in Fatty Acid Metabolism294
Organization and Molecular Interactions of Retinoschisin in Photoreceptors302
Basic Science Underlying Retinal Degeneration309
Proteomics Profiling of the Cone Photoreceptor Cell Line, 661W310
.-Secretase Regulates VEGFR-1 Signallingin Vascular Endothelium and RPE321
Analysis of the Rate of Disk Membrane Digestion by Cultured RPE Cells328
Functional Expression of Cone Cyclic Nucleotide- Gated Channel in Cone Photoreceptor- Derived 661W Cells334
Phosphorylation of Caveolin-1 in Bovine Rod Outer Segments in vitro by an Endogenous Tyrosine Kinase342
Regulation of Neurotrophin Expression and Activity in the Retina349
Involvement of Guanylate Cyclases in Transport of Photoreceptor Peripheral Membrane Proteins356
Rod Progenitor Cells in the Mature Zebrafish Retina365
avß5 Integrin Receptors at the Apical Surfaceof the RPE: One Receptor, Two Functions373
Implantation of Mouse Eyes with a Subretinal Microphotodiode Array380
Variation in the Electroretinogram of C57BL/6 Substrains of Mouse386
A2E, A Pigment of RPE Lipofuscin, is Generated from the Precursor, A2PE by a Lysosomal Enzyme Activity395
Endothelin Receptors: Do They Have a Role in Retinal Degeneration?401
CNTF Negatively Regulates the Phototransduction Machinery in Rod Photoreceptors: Implication for Light- Induced Photostasis Plasticity408
Index418