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Main Data
Author: Nicholas S. Hill, Harrison W. Farber
Title: Pulmonary Hypertension
Publisher: Humana Press
ISBN/ISSN: 9781603270755
Edition: 1
Price: CHF 234.00
Publication date: 01/01/2008
Content
Category: Medizin & Pharmazie
Language: English
Technical Data
Pages: 444
Kopierschutz: DRM
Geräte: PC/MAC/eReader/Tablet
Formate: PDF
Table of contents

This timely volume addresses the areas of pathophysiology and therapy of pulmonary hypertension, which have seen exciting developments over the past decade. The discoveries of endothelin overexpression as well as prostacyclin and nitric oxide deficiency in association with pulmonary hypertension have led to important therapeutic insights. The new therapies have led to significant improvements in patient function, quality of life and survival. In this book, expert authors describe these new therapies. It will be of interest not only to cardiologists, pulmonary specialists and rheumatologists, but also many nurses and pharmacotherapists.

Table of contents
Preface7
Contents9
Contributors11
List of Color Plates15
Historical Perspective: A Century of Primary ( Idiopathic) Pulmonary Hypertension16
1. INTRODUCTION17
2. THE STUDY OF PULMONARY HEMODYNAMICS18
3. CONTROL OF THE PULMONARY CIRCULATION20
4. PULMONARY HEMODYNAMICS IN PRIMARY ( IDIOPATHIC) PULMONARY HYPERTENSION21
5. THE AMINOREX EPIDEMIC22
6. THE FIRST WORLD HEALTH ORGANIZATION MEETING, GENEVA, 197322
7. THE NATIONAL REGISTRY, 198123
8. THE SECOND PULMONARY HYPERTENSION EPIDEMIC23
9. THE SECOND WORLD HEALTH ORGANIZATION MEETING, EVIAN, 199824
10. FAMILIAL IDIOPATHIC PULMONARY ARTERIAL HYPERTENSION24
11. CONCLUSION25
REFERENCES26
Classification of Pulmonary Hypertension30
1. INTRODUCTION31
2. PULMONARY ARTERIAL HYPERTENSION33
3. PULMONARY VENOUS HYPERTENSION39
4. PULMONARY HYPERTENSION ASSOCIATED WITH HYPOXIA40
5. PULMONARY HYPERTENSION DUE TO CHRONIC THROMBOTIC AND/ OR EMBOLIC DISEASE40
6. PULMONARY HYPERTENSION DUE TO MISCELLANEOUS CAUSES41
7. FUNCTIONAL CLASSIFICATION OF PULMONARY HYPERTENSION41
8. CONTROVERSIES42
9. CONCLUSION43
REFERENCES43
Diagnostic Approach to Pulmonary Arterial Hypertension48
1. INTRODUCTION49
2. SUSPICION/HISTORY49
3. PHYSICAL EXAMINATION51
4. NONINVASIVE TESTING52
5. INVASIVE TESTING57
6. LABORATORY TESTING59
7. SUMMARY61
REFERENCES61
Pathophysiology of Pulmonary Arterial Hypertension66
1. INTRODUCTION67
2. IMBALANCE OF VASOACTIVE MEDIATORS68
3. ENVIRONMENTAL ASSOCIATIONS WITH PULMONARY ARTERIAL HYPERTENSION71
4. CONDITIONS ASSOCIATED WITH PULMONARY ARTERIAL HYPERTENSION74
5. GENETIC ABNORMALITIES ASSOCIATED WITH PULMONARY HYPERTENSION78
6. CONCLUSIONS80
REFERENCES81
Pulmonary Hypertension Genes88
1. INTRODUCTION89
2. PEDIGREE ANALYSIS89
3. BONE MORPHOGENIC PROTEIN RECEPTOR90
2 GENE (90
4.93
MUTATIONS IN IPAH93
5.93
IN OTHER PAH COHORTS93
6. BIOLOGY OF94
7.96
AND HEREDITARY HEMORRHAGIC TELANGIECTASIA96
8. MODIFIERS AND TRIGGERS OF PULMONARY ARTERIAL HYPERTENSION96
9. SCREENING/COUNSELING102
REFERENCES103
The Right Ventricle in Pulmonary Hypertension108
1. THE NORMAL RIGHT VENTRICLE AND PULMONARY CIRCULATION109
2. RIGHT VENTRICULAR RESPONSE TO PULMONARY HYPERTENSION111
3. ADAPTIVE AND MALADAPTIVE CARDIAC HYPERTROPHIC RESPONSES112
4. SIGNALING PATHWAYS IN CARDIAC HYPERTROPHY112
5. ADAPTIVE HYPERTROPHY116
6. DETERMINANTS OF THE HYPERTROPHIC RESPONSE OF THE RIGHT VENTRICLE118
7. RIGHT AND LEFT VENTRICULAR INTERACTIONS119
8. PERICARDIAL EFFUSION120
9. EFFECT OF RIGHT HEART FUNCTION ON PATIENT OUTCOME IN PULMONARY HYPERTENSION121
10. MONITORING RIGHT VENTRICULAR FUNCTION122
11. CLINICAL APPROACH TO RV DYSFUNCTION128
12. FUTURE DIRECTIONS131
ACKNOWLEDGMENTS131
REFERENCES132
Congenital Heart Disease Associated with Pulmonary Arterial Hypertension142
1. INTRODUCTION143
2. DYNAMIC PAH144
3. IMMEDIATE-POSTOPERATIVE REACTIVE PULMONARY HYPERTENSION146
4. LATE-POSTOPERATIVE PULMONARY HYPERTENSION148
5. NORMAL TO MILDLY ABNORMAL PVR STATES148
6. EISENMENGER PHYSIOLOGY149
7. CONCLUSIONS154
REFERENCES154
Connective Tissue Disease Associated Pulmonary Hypertension160
1. INTRODUCTION161
2. EPIDEMIOLOGY161
3. PATHOPHYSIOLOGY165
4. CLINICAL PRESENTATION AND DIAGNOSIS167
5. THERAPY OF SSC-PH170
6. SURGICAL TREATMENTS177
7. SUMMARY177
REFERENCES178
Pulmonary Hypertension Associated with HIV, Liver Disease, Sarcoidosis, and Sickle Cell Disease188
1. INTRODUCTION189
2. HIV-ASSOCIATED PULMONARY HYPERTENSION189
3. PORTOPULMONARY HYPERTENSION198
4. SARCOIDOSIS203
5. SICKLE CELL DISEASE203
6. CONCLUSIONS205
REFERENCES206
Chronic Thromboembolic Pulmonary Hypertension214
1. INTRODUCTION215
2. PATHOGENESIS216
3. CLINICAL PRESENTATION AND HISTORY218
4. PHYSICAL EXAMINATION219
5. DIAGNOSTIC EVALUATION219
6. SURGICAL SELECTION228
7. SURGICAL APPROACH230
8. POSTOPERATIVE COURSE232
9. SURGICAL OUTCOME235
10. LONG-TERM OUTCOME236
11. MEDICAL THERAPY236
12. LUNG TRANSPLANTATION238
13. SUMMARY238
REFERENCES238
General Therapeutic Approach and Traditional Therapies246
1. INTRODUCTION247
2. REVERSIBLE FACTORS CONTRIBUTING TO PULMONARY HYPERTENSION247
3. SUMMARY266
REFERENCES266
Prostacyclin Therapy for Pulmonary Arterial Hypertension270
1. INTRODUCTION271
2. PHARMACOLOGICAL ACTIONS OF PROSTACYCLIN272
3. CLINIC