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Autor: Nai-Kong V. Cheung, Susan L. Cohn
Herausgeber: Nai-Kong V. Cheung, Susan L. Cohn
Titel: Neuroblastoma
Verlag: Springer-Verlag
ISBN/ISSN: 9783540266167
Auflage: 1
Preis : CHF 160.10
Erscheinungsdatum:
Inhalt
Kategorie: Medizin & Pharmazie
Sprache: English
Technische Daten
Seiten: 300
Kopierschutz: DRM
Geräte: PC/MAC/eReader/Tablet
Formate: PDF
Inhaltsangabe

Neuroblastoma is a medical enigma. As a childhood neoplasm arising from neural crest cells, it is characterized by diverse clinical behaviors ranging from spontaneous remission to rapid tumor progression and death. Although clinical outcome can be predicted to a large extent by the stage of disease and the age at diagnosis, an in-depth understanding of its clinico-pathological behavior, now greatly aided by sophisticated molecular genetic profiling, will improve diagnostic precision and refine risk-based therapies. Comprehensive international efforts have advanced our understanding of tumor biology and improved the clinical management of children with neuroblastoma. This book reviews our current understanding of the genes and biological pathways that contribute to neuroblastoma pathogenesis, modern risk-based treatment approaches for these patients, and recent advances in biologically based therapy. It provides a concise up-to-date reference for practitioners, students, and researchers.

Inhaltsverzeichnis <
Preface5
Contents6
Contributors12
Epidemiology15
1.1 Descriptive Epidemiology15
1.2 Risk Factors16
1.3 Conclusions18
References19
Screening for Neuroblastoma20
2.1 Introduction20
2.2 The Rationale for Neuroblastoma Screening20
2.3 Early Pioneering Studies Investigating Neuroblastoma Screening in Japan21
2.4 Initial North American and European Neuroblastoma Screening Trials22
2.5 Follow-up Studies from Japan and Europe24
2.6 Definitive Controlled Trials from Quebec and Germany24
2.7 Biologic, Psychologic, Economic, and Clinical Aspects of Neuroblastoma Screening 30
2.8 Conclusions31
References31
Genetics34
3.1 Introduction34
3.2 Associated Genetic Conditions34
3.3 Constitutional Chromosomal Abnormalities35
3.4 Hereditary Neuroblastoma36
3.5 Genetic Studies of Familial Neuroblastoma38
3.6 Conclusions38
References39
Molecular Cytogenetics40
4.1 Introduction40
4.2 Classical Cytogenetics40
4.3 Oncogene Expression Profiling41
4.4 Neuroblastoma Suppressor Genes and Loss of Heterozygosity42
4.5 Comparative Genomic Hybridization47
4.6 Tumor Cell Ploidy47
4.7 Conclusion48
References48
Molecular and Developmental Biology of Neuroblastoma54
5.1 Neural Crest Development and Neuroblastoma54
5.2 Molecular Bases of Differentiation and Programmed Cell Death 58
5.3 Conclusions63
References64
Cellular Heterogeneity67
6.1 Introduction67
6.2 Neural Crest Differentiation67
6.3 Neuroblastoma Cellular Heterogeneity68
6.4 N-type Neuroblastic Cells68
6.5 S-type Non-Neural Cells69
6.6 I-type Stem Cells70
6.7 Transdifferentiation71
6.8 Conclusions72
References72
Clinical Presentation74
7.1 Introduction74
7.2 Diagnosis75
7.3 Clinical Presentation 76
7.4 Differential Diagnosis 83
7.5 Clinical and Laboratory Evaluation 84
7.6 Conclusions93
References94
Pathology of Peripheral Neuroblastic Tumors97
8.1 Introduction97
8.2 Historical Overview98
8.3 Basic Morphology98
8.4 Prognostic Classification102
8.5 Biological Relevance102
8.6 Conclusion104
References104
Molecular Pathology of Neuroblastic Tumors Based on Genome- wide Expression Analysis106
9.1 Introduction106
9.2 Clinical Issues107