Autor: Vassil St.Georgiev, Gail Skowron, Richard Ogden, Joep M. A. Lange
Herausgeber: Gail Skowron, Richard Ogden
Titel: Reverse Transcriptase Inhibitors in HIV/AIDS Therapy
Verlag: Humana Press
ISBN/ISSN: 9781597450850
Auflage: 1
Preis : CHF 234.00
Kategorie: Medizin & Pharmazie
Sprache: English
Technische Daten
Seiten: 528
Kopierschutz: DRM
Geräte: PC/MAC/eReader/Tablet
Formate: PDF
A magisterial survey of all aspects of the reverse transcriptase inhibitors (RTIs) used to treat HIV/AIDS, including drug discovery, pharmacology, development of drug resistance, toxicity, and prevention of mother-to-child transmission of HIV/AIDS. The authors synthesize our current understanding of the role of reverse transcriptase in the viral life cycle, describe the discovery and development of eight nucleoside and nucleotide analogs that represent milestones in treatment history, and thoroughly discuss the question of toxicity and resistance to this class of drugs. They also address three non-nucleoside RTIs and their pharmacokinetics and comparative clinical efficacy, new RTIs currently under development, and the impact of approved agents on treatment, in general, and on vertical transmission in the developing world.