| Preface | 5 |
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| Contents | 8 |
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| Contributors | 11 |
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| Chapter 1 | 18 |
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| Rheumatoid Arthritis | 18 |
| 1.1 Overview of Rheumatoid Arthritis | 18 |
| 1.1.1 Diagnosis | 18 |
| 1.1.2 Clinical Features | 18 |
| 1.1.3 Rheumatoid Arthritis Mimickers | 20 |
| 1.1.4 Serological Features and Radiology | 22 |
| 1.1.5 Risk Factors | 23 |
| 1.1.6 Disease Assessment | 23 |
| 1.1.7 Treatment | 24 |
| 1.1.7.1 Treatment Strategy | 24 |
| 1.1.7.2 Glucocorticoids, Methotrexate, and Conventional DMARDs | 24 |
| 1.1.7.3 Biologic Agents | 26 |
| 1.1.8 Co-Morbidities and Adverse Effects | 27 |
| 1.2 Immunizations in RA | 28 |
| References | 28 |
| Chapter 2 | 31 |
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| Rheumatoid Vasculitis | 31 |
| 2.1 Overview of Rheumatoid Vasculitis | 31 |
| References | 37 |
| Chapter 3 | 39 |
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| Adult-Onset Stills Disease | 39 |
| References | 42 |
| Chapter 4 | 43 |
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| Juvenile Idiopathic Arthritis | 43 |
| 4.1 Overview of Juvenile Idiopathic Arthritis | 43 |
| References | 47 |
| Chapter 5 | 49 |
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| Monogenic Autoinflammatory Syndromes | 49 |
| 5.1 Overview of the Monogenic Autoinflammatory Syndromes | 49 |
| 5.1.1 Familial Mediterranean Fever | 49 |
| 5.1.2 Tumor Necrosis Factor Receptor-Associated Periodic Syndrome (TRAPS) | 54 |
| 5.1.3 Hyper Immunoglobulin D and Periodic Fever Syndrome | 55 |
| 5.1.4 Cryopyrin-Associated Periodic Syndromes | 56 |
| 5.1.5 Chronic Recurrent Multifocal Osteomyelitis | 59 |
| 5.1.6 PAPA | 60 |
| 5.1.7 Cherubism | 61 |
| References | 62 |
| Chapter 6 | 66 |
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| Juvenile Spondyloarthropathy | 66 |
| 6.1 Overview | 66 |
| References | 70 |
| Chapter 7 | 72 |
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| Ankylosing Spondylitis | 72 |
| 7.1 Overview of Ankylosing Spondylitis | 72 |
| References | 79 |
| Chapter 8 | 81 |
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| Psoriatic Arthritis | 81 |
| 8.1 Overview of Psoriatic Arthritis | 81 |
| References | 84 |
| Chapter 9 | 86 |
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| Reactive Arthritis | 86 |
| 9.1 Overview of Reactive Arthritis | 86 |
| References | 89 |
| Chapter 10 | 90 |
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| Systemic Sclerosis (Scleroderma) and Raynauds Phenomenon | 90 |
| 10.1 Overview of Systemic Sclerosis | 90 |
| 10.1.1 Raynauds Phenomenon and Digital Ischemia | 90 |
| 10.1.2 Diagnosis | 93 |
| 10.1.3 Autoantibodies and Disease Phenotypes | 93 |
| 10.1.4 Skin Disease | 96 |
| 10.1.5 Gastrointestinal Involvement | 97 |
| 10.1.6 Interstitial Lung Disease | 98 |
| 10.1.7 Pulmonary Arterial Hypertension | 101 |
| 10.1.8 Cardiac Disease | 103 |
| 10.1.9 Scleroderma Renal Crisis | 103 |
| 10.1.10 Musculoskeletal Manifestations | 104 |
| 10.1.11 Peripheral Neuropathy in SSc | 106 |
| References | 106 |
| Chapter 11 | 109 |
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| Nephrogenic Systemic Fibrosis and Other Scleroderma Mimickers | 109 |
| 11.1 Overview of Nephrogenic Systemic Fibrosis and Other Scleroderma Mimickers | 109 |
| 11.2 Localized Scleroderma | 115 |
| 11.3 Morphea | 115 |
| 11.4 Scleromyxedema | 116 |
| 11.5 Eosinophilic Fasciitis | 117 |
| References | 117 |
| Chapter 12 | 119 |
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| Sjögrens Syndrome | 119 |
| 12.1 Overview of Sjögrens Syndrome | 119 |
| 12.2 Classification and Epidemiology | 119 |
| 12.3 Pathogenesis | 121 |
| 12.4 Sicca Features | 121 |
| 12.4.1 Ocular Manifestations | 121 |
| 12.4.2 Oral Manifestations | 123 |
| 12.5 Parotid and Submandibular Involvement | 127 |
| 12.6 Extraglandular Involvement | 128 |
| 12.7 Laboratory Findings | 134 |
| 12.8 Immunological Assays | 135 |
| 12.9 Differential Diagnosis | 136 |
| 12.10 Prognosis and Outcome | 137 |
| 12.11 Systemic Treatment | 138 |
| References | 138 |
| Chapter 13 | 143 |
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| Systemic Lupus Erythematosus | 143 |
| 13.1 Overview of Systemic Lupus Erythematosus | 143 |
| 13.2 Diagnosis | 143 |
| 13.3 Clinical Features | 145 |
| 13.4 Cutaneous Lupus | 148 |
| 13.5 Lupus Nephritis | 157 |
| 13.6 Central Nervous System Lupus | 158 |
| 13.7 General Management Points | 160 |
| 13.8 Treatment | 164 |
| References | 167 |
| Chapter 14 | 172 |
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| Pediatric Systemic Lupus Erythematosus | 172 |
| References | 176 |
| Chapter 15 | 179 |
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| Mixed Connective Tissue Disease | 179 |
| Overview of Mixed Connective Tissue Disease | 179 |
| References | 182 |
| Chapter 16 | 183 |
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| The Antiphospholipid Syndrome | 183 |
| 16.1 Overview of the Antiphospholipid Syndrome | 183 |
| 16.2 Risk Factors for Thrombosis in APS | 185 |
| References | 189 |
| Chapter 17 | 191 |
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| Pregnancy in the Rheumatic Diseases | 191 |
| 17.1 Overview of Pregnancy in the Rheumatic Diseases |