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& Myths in Rheumatology

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Main Data

Author:	John Stone
Editor:	John H. Stone
Title:	& Myths in Rheumatology
Publisher:	Springer-Verlag
ISBN/ISSN:	9781848009349
Edition:	1
Price:	CHF 135.50
Publication date:	01/01/2009

Content

Category:	Medizin & Pharmazie
Language:	English

Technical Data

Pages:	493
Kopierschutz:	DRM
Geräte:	PC/MAC/eReader/Tablet
Formate:	PDF

Table of contents

Important strides have been made in understanding the pathophysiologic basis of many inflammatory conditions in recent years, but rheumatology remains a discipline in which diagnosis is rooted in the medical history skillfully extracted from the patient, the careful physical examination, and the discriminating use of laboratory tests and imaging. Moreover, selection of the most appropriate therapy for patients with rheumatic diseases also remains heavily reliant upon clinical experience. Medical disciplines such as rheumatology that depend significantly upon clinical wisdom are prone to the development of systems of 'Pearls' and 'Myths,' related to the diseases they call their own, a 'Pearl' being a nugget of truth about the diagnosis or treatment of a particular disease that has been gained by dint of clinical experience and a 'Myth' being a commonly held belief that influences the practice of many clinicians - but is false. This book will pool together the clinical wisdom of seasoned, expert rheumatologists who participate in the care of patients with autoimmune diseases, systemic inflammatory disorders, and all other rheumatic conditions.

Table of contents

	Preface	5
	Contents	8
	Contributors	11
	Chapter 1	18
	Rheumatoid Arthritis	18
	1.1 Overview of Rheumatoid Arthritis	18
	1.1.1 Diagnosis	18
	1.1.2 Clinical Features	18
	1.1.3 Rheumatoid Arthritis Mimickers	20
	1.1.4 Serological Features and Radiology	22
	1.1.5 Risk Factors	23
	1.1.6 Disease Assessment	23
	1.1.7 Treatment	24
	1.1.7.1 Treatment Strategy	24
	1.1.7.2 Glucocorticoids, Methotrexate, and Conventional DMARDs	24
	1.1.7.3 Biologic Agents	26
	1.1.8 Co-Morbidities and Adverse Effects	27
	1.2 Immunizations in RA	28
	References	28
	Chapter 2	31
	Rheumatoid Vasculitis	31
	2.1 Overview of Rheumatoid Vasculitis	31
	References	37
	Chapter 3	39
	Adult-Onset Stills Disease	39
	References	42
	Chapter 4	43
	Juvenile Idiopathic Arthritis	43
	4.1 Overview of Juvenile Idiopathic Arthritis	43
	References	47
	Chapter 5	49
	Monogenic Autoinflammatory Syndromes	49
	5.1 Overview of the Monogenic Autoinflammatory Syndromes	49
	5.1.1 Familial Mediterranean Fever	49
	5.1.2 Tumor Necrosis Factor Receptor-Associated Periodic Syndrome (TRAPS)	54
	5.1.3 Hyper Immunoglobulin D and Periodic Fever Syndrome	55
	5.1.4 Cryopyrin-Associated Periodic Syndromes	56
	5.1.5 Chronic Recurrent Multifocal Osteomyelitis	59
	5.1.6 PAPA	60
	5.1.7 Cherubism	61
	References	62
	Chapter 6	66
	Juvenile Spondyloarthropathy	66
	6.1 Overview	66
	References	70
	Chapter 7	72
	Ankylosing Spondylitis	72
	7.1 Overview of Ankylosing Spondylitis	72
	References	79
	Chapter 8	81
	Psoriatic Arthritis	81
	8.1 Overview of Psoriatic Arthritis	81
	References	84
	Chapter 9	86
	Reactive Arthritis	86
	9.1 Overview of Reactive Arthritis	86
	References	89
	Chapter 10	90
	Systemic Sclerosis (Scleroderma) and Raynauds Phenomenon	90
	10.1 Overview of Systemic Sclerosis	90
	10.1.1 Raynauds Phenomenon and Digital Ischemia	90
	10.1.2 Diagnosis	93
	10.1.3 Autoantibodies and Disease Phenotypes	93
	10.1.4 Skin Disease	96
	10.1.5 Gastrointestinal Involvement	97
	10.1.6 Interstitial Lung Disease	98
	10.1.7 Pulmonary Arterial Hypertension	101
	10.1.8 Cardiac Disease	103
	10.1.9 Scleroderma Renal Crisis	103
	10.1.10 Musculoskeletal Manifestations	104
	10.1.11 Peripheral Neuropathy in SSc	106
	References	106
	Chapter 11	109
	Nephrogenic Systemic Fibrosis and Other Scleroderma Mimickers	109
	11.1 Overview of Nephrogenic Systemic Fibrosis and Other Scleroderma Mimickers	109
	11.2 Localized Scleroderma	115
	11.3 Morphea	115
	11.4 Scleromyxedema	116
	11.5 Eosinophilic Fasciitis	117
	References	117
	Chapter 12	119
	Sjögrens Syndrome	119
	12.1 Overview of Sjögrens Syndrome	119
	12.2 Classification and Epidemiology	119
	12.3 Pathogenesis	121
	12.4 Sicca Features	121
	12.4.1 Ocular Manifestations	121
	12.4.2 Oral Manifestations	123
	12.5 Parotid and Submandibular Involvement	127
	12.6 Extraglandular Involvement	128
	12.7 Laboratory Findings	134
	12.8 Immunological Assays	135
	12.9 Differential Diagnosis	136
	12.10 Prognosis and Outcome	137
	12.11 Systemic Treatment	138
	References	138
	Chapter 13	143
	Systemic Lupus Erythematosus	143
	13.1 Overview of Systemic Lupus Erythematosus	143
	13.2 Diagnosis	143
	13.3 Clinical Features	145
	13.4 Cutaneous Lupus	148
	13.5 Lupus Nephritis	157
	13.6 Central Nervous System Lupus	158
	13.7 General Management Points	160
	13.8 Treatment	164
	References	167
	Chapter 14	172
	Pediatric Systemic Lupus Erythematosus	172
	References	176
	Chapter 15	179
	Mixed Connective Tissue Disease	179
	Overview of Mixed Connective Tissue Disease	179
	References	182
	Chapter 16	183
	The Antiphospholipid Syndrome	183
	16.1 Overview of the Antiphospholipid Syndrome	183
	16.2 Risk Factors for Thrombosis in APS	185
	References	189
	Chapter 17	191
	Pregnancy in the Rheumatic Diseases	191
	17.1 Overview of Pregnancy in the Rheumatic Diseases