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Main Data
Editor: Dimitrios Kardamakis, Vassilios Vassiliou, Edward Chow
Title: Bone Metastases A translational and clinical approach
Publisher: Springer-Verlag
ISBN/ISSN: 9781402098192
Edition: 1
Price: CHF 209.40
Publication date: 01/01/2009
Content
Category: Medizin & Pharmazie
Language: English
Technical Data
Pages: 400
Kopierschutz: DRM
Geräte: PC/MAC/eReader/Tablet
Formate: PDF
Table of contents

Bone Metastases: A Translational and Clinical Approach serves as both an introductory and reference book focusing on the field of metastatic bone disease. Featuring contributions from experts in the field, this volume:

  • describes the molecular and cellular mechanisms involved in the formation of bone metastases,
  • comments on the role of angiogenesis,
  • presents the newer advances made in the understanding of the clinical picture and symptoms of patients,
  • analyses the role of bone markers in research and clinical practice
  • deals with all aspects of imaging modalities applied for the detection and evaluation of bone metastases.

This volume also covers the use of radiotherapy, surgery and systemic treatments for the management of metastatic bone disease and new therapeutic approaches. Moreover it may also serve as a guide for the clinical and therapeutic management of patients with metastatic bone disease.

Overall this volume presents a thorough overview of all aspects of metastatic bone disease and provides a comprehensive and concise information resource for medical researchers, oncologists, orthopaedic surgeons and clinicians.

Table of contents
Preface by Editors7
Contents9
Contributors12
Part I Fundamental Concepts of Bone Metastases16
BONE ANATOMY, PHYSIOLOGY AND FUNCTION17
PATHOPHYSIOLOGY OF BONE METASTASES44
ANGIOGENESIS AND BONE METASTASIS: IMPLICATIONS FOR DIAGNOSIS, PREVENTION AND TREATMENT64
NATURAL HISTORY, PROGNOSIS, CLINICAL FEATURES AND COMPLICATIONS OF METASTATIC BONE DISEASE90
BONE BIOMARKERS IN RESEARCH AND CLINICAL PRACTICE106
Part II Imaging Modalities130
RADIOLOGIC EVALUATION OF SKELETAL METASTASES: ROLE OF PLAIN RADIOGRAPHS AND COMPUTED TOMOGRAPHY131
THE CONTRIBUTION OF NUCLEAR MEDICINE IN THE DIAGNOSIS OF BONE METASTASES149
MAGNETIC RESONANCE IMAGING OF METASTATIC BONE DISEASE174
Part III Therapeutic Strategies193
RADIOTHERAPY AND BONE METASTASES194
BIPHOSPHONATES IN THE MANAGEMENT OF METASTATIC BONE DISEASE203
COMBINED RADIOTHERAPY AND BISPHOSPHONATES: STATE OF ART240
BIPHOSPHONATES IN THE TREATMENT OF BONE METASTASES  OSTEONECROSIS OF THE JAW258
SURGICAL MANAGEMENT OF BONE METASTASES270
THE ROLE OF CHEMOTHERAPY IN THE TREATMENT OF BONE METASTASES294
HORMONOTHERAPY OF BONE METASTASES305
RADIONUCLIDE THERAPY327
Part IV Assessment of Therapeutic Response348
ASSESSMENT OF THERAPEUTIC RESPONSE349
OUTCOME MEASURES IN BONE METASTASES CLINICAL TRIALS375
Index399